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Angiology
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Age-Dependent Changes of Collagen and Elastin Content in Human Aorta and Pulmonary Artery

Yasuhiro Hosoda

From the Departments of Pathology and Clinical Laboratories, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Koichi Kawano

From the Departments of Pathology and Clinical Laboratories, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Fumihiro Yamasawa

From the Departments of Pathology and Clinical Laboratories, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Toshiharu Ishii

From the Departments of Pathology and Clinical Laboratories, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Tetsuichi Shibata

Seiichi Inayama

Collagen and elastin in the arterial wall are thought to show some age-dependent changes, and to relate with development of the arteriosclerotic lesion.

Both aortas and the pulmonary trunks were collected from 137 autopsy cases. Biochemical determination of collagen and elastin content was carried out. Collagen and elastin of the aorta and the pulmonary artery showed no significant age-dependent changes. Elastin content of the pulmonary artery increases with age in the adult.

This paper seems to be the first report of simultaneous estimation of collagen and elastin content of both the aorta and the pulmonary artery.

Angiology, Vol. 35, No. 10, 615-621 (1984)
DOI: 10.1177/000331978403501001
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