This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Egan, T.J. Articles by Thakar, D.R. Search for Related Content PubMed PubMed Citation Articles by Egan, T.J. Articles by Thakar, D.R. Social Bookmarking                         What's this?

Human Amnion in the Management of Chronic Ulceration of the Lower Limb: A Clinico-Pathologic Study

Departments of Surgery and Pathology, Limerick Regional Hospital, Limerick, Ireland

J. O'Driscoll

Departments of Surgery and Pathology, Limerick Regional Hospital, Limerick, Ireland

D.R. Thakar

Departments of Surgery and Pathology, Limerick Regional Hospital, Limerick, Ireland

This study shows that unmodified human amnion can make a useful con tribution to the management of venous ulceration. By suppressing infection, and, by providing a healthy granulating surface, it significantly reduces the pre-skin graft preparation time, when compared with a conventional method of treatment. However, it does not seem to significantly influence the prospects of graft take, or of long term graft survival, in this comparison.

A reversion towards normal of local vasculature, as characterized by vessel wall thinning and widening of the lumen, appears to be a significant tissue change induced by amnion treatment. Such a change may have considerable relevance in any analysis of the basis of the therapeutic efficacy of amnion.

Angiology, Vol. 34, No. 3, 197-203 (1983)
DOI: 10.1177/000331978303400306


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?