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Effect of Coronary Vasodilating Drug on Myocardial Work

Memorial Heart Research Foundation, Los Angeles, St. Vincent Medical Center, University of Southern California, School of Medicine

David W. Winsor

Diplomate of the American Board of Nuclear Medicine, St. Vincent Medical Center

Bernard G. Krohn

St. Vincent Medical Center

Jorge R. Bernett

Research Assistant for Memorial Heart Research Foundation

The purpose of this paper is to show, by noninvasive measurements, previously undocumented effects on cardiac work of the nitrate coronary vasodilator Pentaerythritol Tetranitrate (Peritrate®). The chew-and-swallow 40-mg tablets of this drug were given to 10 patients of type II AHA classifica tion. The Diastolic Time Tension Index/Systolic Time Tension Index Ratio increased significantly from 1.15 (±0.11 SEM) to 1.46 (±0.13), p<0.05. The Double Product decreased significantly from 9813 (±606) to 8336 (±497), p<0.01. The Triple Product also decreased significantly from 3223 (±235) to 2425 (±206), p<0.01. The percent diastole of the R-R interval increased signifi cantly from 65% (±2.44) to 70% (± 1.73) p<0.05, while no significant change in heart rate occurred (63.2 bts/min to 62.4 bts/min). Correspondingly, there was a decrease of systolic time interval, from 0.33 second (±0.2) to 0.29 second (±.01) p<0.01. A significant decrease in blood pressure was also noted. Sys tolic BP dropped from 155 (±8.0) to 134(±7.2),p<0.01. Diastolic BP dropped from 89.2 (±2.8) to 79.2 (±2.2), p<0.01. This study shows that Peritrate produced significantly favorable changes in all the cited indicators of cardiac work.

Angiology, Vol. 33, No. 6, 393-400 (1982)
DOI: 10.1177/000331978203300605


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