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Angiology
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Platelet Aggregation in Patients With Moyamoya Disease

Yutaka Maki

Department of Neurological Surgery and the Department of Internal Medicine, School of Medicine, The University of Tsukuba, Ibaraki, Japan

Tadao Nose

Department of Neurological Surgery and the Department of Internal Medicine, School of Medicine, The University of Tsukuba, Ibaraki, Japan

Kenjiro Tanoue

Department of Neurological Surgery and the Department of Internal Medicine, School of Medicine, The University of Tsukuba, Ibaraki, Japan

Tsukasa Abe

Department of Neurological Surgery and the Department of Internal Medicine, School of Medicine, The University of Tsukuba, Ibaraki, Japan

Platelet aggregation was studied by giving ADP or adrenalin to 28 patients with Moyamoya disease. There were 7 males and 21 females, and 27 normal controls, 11 males and 16 females. We found that 2 µM of ADP, and 9.1 and 22.7 µM of adrenalin induced statistically significant increases in nondisso ciative patterns of platelet aggregation in the patient group. Maximum aggregation was significantly increased in the patient group compared with the controls by the addition of ADP (2 and 4 µM) or adrenalin (9.1 and 22.7 µM). When patients were divided into two groups under and over 20 years of age, there was no discernible difference of platelet aggregation in either group.

Angiology, Vol. 32, No. 8, 522-528 (1981)
DOI: 10.1177/000331978103200802
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