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Angiology
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Influence of Non-Selective and Selective Beta Adrenoceptor Blockade on Isoxsuprine-Dependent Hemodynamic and Rheologic Changes

T. Di Perri

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

S. Forconi

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

M. Guerrini

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

S. Pecchi

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

D. Pieragalli

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

R. Cappelli

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

A. Acciavatti

Istituto di Patologia Speciale Medica e Metodologia Clinica, School of Medicine, University of Siena, Siena, Italy

The infusion of isoxsuprine was followed by an increase of heart rate and calf blood flow and by a decrease of arterial diastolic pressure and blood viscosity both in normal controls and patients with peripheral obstructive arterial disease. The pre-treatment with a non-selective beta adrenoceptor blocker (propranolol) canceled all the isoxsuprine-dependent changes, while the pre-treatment with a selective beta adrenoceptor blocker (metoprolol) abolished only tachycardia and did not influence the increase of calf blood flow and the decrease of blood viscosity. These findings indicate the different role of vascular beta receptors in the regulation of muscular blood flow and suggest the pharmacologic possibility to unmask the beta2-dependent vaso dilation.

Angiology, Vol. 32, No. 4, 257-265 (1981)
DOI: 10.1177/000331978103200406
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This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
F. Laghi Pasini, S. Pecchi, F. Guideri, V. DeFranco, P. Damiani, C. Galigani, M. Saletti, M.S. Verzuri, P. Blardi, and T. Di Perri
Hemodynamic and Hemorheologic Effects of IV Dilevalol in Hypertensive Patients
Angiology, September 1, 1991; 42(9): 703 - 710.
[Abstract] [PDF]

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 ANGIOLOGYHome page
S.H. Skotnicki, G. van Gaal, and P.F.F. Wijn
The Effectiveness of Isoxsuprine in Patients With Intermittent Claudication
Angiology, November 1, 1984; 35(11): 685 - 693.
[Abstract] [PDF]


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