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Effect of the Kallikrein Inhibitor Aprotinin on Myocardial Ischemia and Necrosis in ManUniversity of Sonora, Hermosillo, Sonora, Mexico
University of Sonora, Hermosillo, Sonora, Mexico The effect of administration of aprotinin, a serine esterase inhibitor capable of inactivating kallikrein, on the extent and severity of acute myocardial is chemic injury and subsequent necrosis, was studied in 25 patients. Another group of 25 patients who did not receive aprotinin served as a control group. We administered 100,000 kallikrein inhibitor units (KIU) of aprotinin as a bolus dose, followed by a continuous infusion (4 ml/min) that contained 10,000 KIU/kg in 240 ml of dextrose/water solution, to all 25 patients admitted to the hospital within 30 to 60 minutes after the onset of acute myocardial ischemia.
To measure the effect of aprotinin, three parameters were studied; the sum of S-T segment elevations (
The average In the control group the estimated infarct size was 57.4 ± 4 CPK-gram- equivalents (CPK-g-Eq). There was significantly less damage in the treated group: 19 ± 2 CPK-g-Eq (P < 0.01). Thus we conclude that aprotinin dimin ishes myocardial damage.
Angiology, Vol. 31, No. 7,
488-496 (1980) This article has been cited by other articles:
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ST), the development of Q waves, and the predic tion of infarct size by measuring the disappearance rate of creatine phosphoki nase (MB CPK isoenzyme). 
Q (6 hours) = 1.0 ST (15 min) + 1.19 (25 patients, r = 0.78); and in the treated group 
