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Angiology
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Systolic Time Intervals: A Valuable Parameter of Thyroid Function

Walter J. Paulus

Ronald Ranquin

Gaston Parizel

Conventional systolic time interval measurements were made in 49 patients presenting with hypertyroidism, euthyroidism, or hypothyroidism. A linear correlation was observed over the entire range of thyroid function (r = 0.75) between {Delta} PEP and the serum free T4 index. A linear correlation was also found between the PEP/LVET ratio and the serum free T4 index (r = 0.70). A higher correlation was found between the PEP/LVET ratio and the serum free T4 index when plotted logarithmically (r = 0.75).

During treatment of hyperthyroidism, the PEP progressively lengthens and the PEP/LVET ratio increases, whereas during treatment of hypothyroidism the PEP shortens progressively to normal values while the PEP/LVET ratio diminishes.

In amiodarone-induced hyperthyroidism, both a prolonged PEP and an increased PEP/LVET ratio were found. These controversial measurements, suggesting a diminished cardiac contractility, may be explained by a worsened cardiac ischemia due to the development of hyperthyroidism.

Systolic time interval measurements appear to be a valuable tool in the assessment of the cardiac response to thyroid hormone during both hypothyroidism and hyperthyroidism.

Angiology, Vol. 31, No. 2, 100-108 (1980)
DOI: 10.1177/000331978003100204
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