SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Jageneau, A.H.M.
Right arrow Articles by Symoens, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jageneau, A.H.M.
Right arrow Articles by Symoens, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Plethysmographic Registration of Volume Changes in a Hand Vein Effects of Serotonin and of a Specific Antagonist

A.H.M. Jageneau

From the Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium

Ch. Hörig

From the Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium

W. Loots

From the Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium

J. Symoens

From the Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium

The influence of serotonin on a selected dorsal hand vein can be evaluated by changes in tangential wall tension, volume, and pressure. A plethysmo graphic method has been used to record the changes in venous capacitance at constant pressure after IV injection of small doses of serotonin.

R 41 468, a specific serotonin antagonist, has been given orally (10, 20, or 40 mg) or intravenously (2.5 or 10 mg) to healthy volunteers. A reduction or a complete blockade of activity of serotonin was observed after all doses of R 41 468. Duration and strength of the antagonism were dose-dependent.

This pharmacologic in vivo model allows investigations into substances with an effect on vascular smooth muscles.

Angiology, Vol. 31, No. 12, 828-832 (1980)
DOI: 10.1177/000331978003101203
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
E. Arosio, G. Montesi, M. Zannoni, F. Paluani, and A. Lechi
Comparative Efficacy of Ketanserin and Pentoxiphylline in Treatment of Raynaud's Phenomenon
Angiology, July 1, 1989; 40(7): 633 - 638.
[Abstract] [PDF]


Advertisement