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Angiotensin-Converting Enzyme Inhibitor (SQ 20881) in the Diagnosis of Renovascular Hypertension

Department of Internal Medicine, the Hypertension Unit, Department of General Surgery and Transplantations, Department of General and Vascular Surgery, the Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

E. Kissin

Department of Internal Medicine, the Hypertension Unit, Department of General Surgery and Transplantations, Department of General and Vascular Surgery, the Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

E.T. Jacob

Department of Internal Medicine, the Hypertension Unit, Department of General Surgery and Transplantations, Department of General and Vascular Surgery, the Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

N. Stern

Department of Internal Medicine, the Hypertension Unit, Department of General Surgery and Transplantations, Department of General and Vascular Surgery, the Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

Y. Levi

Department of Internal Medicine, the Hypertension Unit, Department of General Surgery and Transplantations, Department of General and Vascular Surgery, the Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

R. Adar

Department of Internal Medicine, the Hypertension Unit, Department of General Surgery and Transplantations, Department of General and Vascular Surgery, the Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

SQ 20881, an angiotensin-converting enzyme inhibitor, was given to 12 patients with renovascular hypertension and to 1 patient with unilateral pa renchymatous renal disease in order to evaluate the role of renin-angiotensin systems in their hypertension. Plasma renin activity (PRA) and aldosterone were assayed in systemic blood before and after the injection of SQ 20881. In 5 patients PRA was also measured separately in each renal vein. Blood pressure decreased, PRA increased, and aldosterone level decreased in the 12 renin- dependant patients. When PRA was sampled separately from each renal vein, the increase was larger on the side of the affected kidney. Four patients with a positive test underwent corrective surgery, and in all blood pressure became normal. SQ 20881 is a useful agent in evaluating the contribution of renin in patients with hypertension.

Angiology, Vol. 30, No. 2, 123-128 (1979)
DOI: 10.1177/000331977903000206


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