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Angiology
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Serial Hemodynamic Studies During the Treatment of Congestive Heart Failure With Isolated Low-Dose Oral Prazosin Therapy

Philippe Reyns

Institute for Cardiovascular Diseases, Good Samaritan Hospital, Phoenix, Arizona

David Romney

Institute for Cardiovascular Diseases, Good Samaritan Hospital, Phoenix, Arizona

Kenneth B. Desser

Institute for Cardiovascular Diseases, Good Samaritan Hospital, Phoenix, Arizona

Alberto Benchimol

Institute for Cardiovascular Diseases, Good Samaritan Hospital, Phoenix, Arizona

Prazosin was administered orally at a maximal dose of 2 mg every 6 hours to 4 patients with congestive heart failure (CHF) who had not received either digitalis or diuretics for 72 hours before therapy. Three of the 4 patients had hypertensive and arteriosclerotic heart disease. Hemodynamic monitoring in dicated a significant reduction of preload and afterload with a concomitant rise in the cardiac index. We concluded that isolated low-dose oral prazosin has salutary effects on indices of hemodynamic function in selected patients.

Angiology, Vol. 30, No. 12, 850-855 (1979)
DOI: 10.1177/000331977903001209
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