This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Stefanini, M. Articles by Urbas, J. E. Search for Related Content PubMed PubMed Citation Articles by Stefanini, M. Articles by Urbas, J. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB GUANETHIDINE METHYLDOPA SODIUM Social Bookmarking                         What's this?

Gaisböck's Syndrome: Its Hematologic, Biochemical and Hormonal Parameters

John V. Urbas

John E. Urbas

The syndrome of plethora without splenomegaly, leukocytosis, or throm bocytosis was described by Gaisböck in 1905. It was reevaluated in 25 patients through the study of numerous hematologic and biochemical parameters. Sta tistically significant findings included mild obesity; elevation of blood pressure (especially diastolic); decrease in plasma volume with relative increase in red cell count, hemoglobin, hematocrit, viscosity of blood, elevation of plasma proteins, serum cholesterol, triglycerides, uric acid, and plasma renin; and increased excretion of urinary sodium. The reduction in plasma volume seemed related to the elevation of the diastolic blood pressure, and favorable through temporary therapeutic results were produced by some antihypertensive agents.

The elevation of serum cholesterol, triglycerides, and uric acid, the increased blood viscosity, and the elevated plasma renin were reminescent of the biochem ical changes observed in some instances of hypertension and atherosclerotic disease. They may explain why patients with the Gaisböck's syndrome belong to the high risk group of hypertensive individuals who often develop cardiovascu lar complications. While its long-term effects remain to be evaluated, treatment with nondiuretic antihypertensive drugs may help reduce the incidence of these complications.

Angiology, Vol. 29, No. 7, 520-533 (1978)
DOI: 10.1177/000331977802900703


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. A. Dormandy, C.J.P. Yates, and G.A. Berent Clinical Relevance of Blood Viscosity and Red Cell Deformability Including Newer Therapeutic Aspects Angiology, April 1, 1981; 32(4): 236 - 242. [Abstract] [PDF]