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Deep Vein Thrombosis Treated With Streptokinase or Heparin

A Randomized Study

Departments of Medicine, University of Oregon Health Sciences Center

Herbert H. Common

Departments of Medicine, University of Oregon Health Sciences Center

Josef Rösch

Department of Diagnostic Radiology, University of Oregon Health Sciences Center

Charles T. Dotter

Department of Diagnostic Radiology, University of Oregon Health Sciences Center

John M. Porter

Department of Surgery, School of Medicine, University of Oregon Health Sciences Center, Portland, Oregon

Thomas D. Lindell

Department of Surgery, School of Medicine, University of Oregon Health Sciences Center, Portland, Oregon

Lliam L. Lawler

Departments of Medicine, University of Oregon Health Sciences Center

William J. Schlueter

Departments of Medicine, University of Oregon Health Sciences Center

Randomly assigned streptokinase or heparin therapy was studied in 50 patients with deep vein thrombosis of less than 2 weeks' duration. Veno graphy was performed prior to therapy, after 3 days, and after 10 days. Two radiologists who were unaware of the patient's therapy compiled a single average lytic score for each patient at each time interval. Lysis of venous thrombi was significantly greater with streptokinase than with heparin after 3 days, but not after 10 days of treatment. Lytic scores achieved with streptokinase were significantly better than those achieved with heparin therapy (P < .01) in male patients who were symptomatic for 3 days or less. In females, regardless of the duration of symptoms, throm bolytic results obtained with streptokinase were not significantly different than results obtained with heparin.

Angiology, Vol. 27, No. 10, 549-556 (1976)
DOI: 10.1177/000331977602701001


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