SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Fragopoulou, E.
Right arrow Articles by Stefanadis, C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fragopoulou, E.
Right arrow Articles by Stefanadis, C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

N-Terminal ProBNP Distribution and Correlations With Biological Characteristics in Apparently Healthy Greek Population: ATTICA Study

Elizabeth Fragopoulou, PhD*, Demosthenes B. Panagiotakos, Christos Pitsavos, Christina Chrysohoou, Tzortzis Nomikos, Angelos Evangelopoulos:, Christina Katsagoni, John Skoumas, Smaragdi Antonopoulou, and Christodoulos Stefanadis

* To whom correspondence should be addressed. E-mail: efragop{at}hua.gr.


  Abstract
Brain natriuretic peptides are widely used as biomarkers of cardiovascular diseases and mainly heart failure. However, these markers are often found to be high even in apparently healthy participants, and little is known about which factors contribute to physiological change in plasma brain natriuretic peptide (BNP) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration in general populations. In this study, a random subsample of the ATTICA study was used (486 individuals) and serum NT-proBNP was measured. Approximately 20% of the participants had no detectable NT-proBNP values. Women had higher values of NT-proBNP than men (median [25th-75th percentiles]: 30.2 [15.8-54.3] vs 14.9 [4.0-28.1] pg/mL, P < .001]. Amino-terminal pro-B-type natriuretic peptide values were positively correlated with age ({rho} = .140, P = .006) and inversely with body mass index (BMI; {rho} = -.142, P = .005), creatinine (Cr) clearance ({rho} = -.349, P < .001), and hemoglobin ({rho} = -.249, P < .001) values. Linear regression analysis revealed that gender is the main contributor of NT-proBNP levels, followed by age, BMI, and Cr values.

First published on October 8, 2009
Angiology 2009, doi:10.1177/0003319709350134
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement