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Effect of Reactive Hyperemia on Carotid-Radial Pulse Wave Velocity in Hypertensive Participants and Direct Comparison With Flow-Mediated Dilation: A Pilot Study

^* To whom correspondence should be addressed. E-mail: jason.lazar{at}downstate.edu.

	Abstract

This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 ± 1.2 to 7.1 ± 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (PWV) response differed between the groups (-16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to PWV (R² = .43, P < .01). Among patients with cardiovascular risk factors/disease, PWV was inversely related to flow-mediated dilation (FMD; R² = .43, P < .003). Conclusion: hyperemia decreases PWV_1min in NT but not in HT. PWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.

First published on July 21, 2009
Angiology 2009, doi:10.1177/0003319709335028


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