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Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease
Leo Moro, MD*,
Claudio Pedone, MD, PhD, MPH,
Simone Scarlata, MD,
Vincenzo Malafarina, MD,
Filippo Luca Fimognari,
and
Raffaele Antonelli-Incalzi, MD
Universita Campus Biomedico
* To whom correspondence should be addressed. E-mail: l.moro{at}unicampus.it.
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Abstract |
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Background: Cardiovascular diseases are prevalent in people with chronic obstructive pulmonary disease (COPD). We hypothesized that endothelial dysfunction could be a marker of the proatherogen status in COPD. Methods and results: We measured endothelial dysfunction by flow-mediated dilation (FMD) and after sublingual administration of nitroglycerin (nitratemediated dilation: NMD) in 44 COPD patients and 48 controls. Compared with controls COPD patients had worse mean FMD (5.4% vs 8.2%, P <.001) and NMD (12.0% vs 13.9%, P </I>=.007). FMD was inversely related to FEV1/VC ratio (r =-0.327, P =.030). The negative association between COPD and FMD was confirmed after correction for potential confounders in a multiple linear regression model ( =-0.019, P = .002). In the same model NMD (=0.396, P <.001) was positively associated with FMD. Conclusions: Endothelial-dependent and, to a lesser extent, endothelial-independent dilations are significantly impaired in COPD, and the impairment is proportional to the severity of bronchial obstruction.
First published on April 2, 2008, doi:10.1177/0003319707306141
Angiology 2008;59:357.
A more recent version of this article appeared on July 1, 2008
This version was published on April
18, 2008
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